Formulation and evaluation of tenoxicam capsules

ABSTRACT

With the aim of preparing tenoxicam capsules, different additives commonly used in capsule formulation were used for the preparation of tenoxicam capsules. Twenty-four different capsule formulae were prepared and were subjected to an in vitro dissolution study using the USP dissolution tester. The anti-inflammatory activity was determined using the rat paw edema technique taking indomethacin as a standard for comparison. The study revealed that there was a significant difference between indomethacin and tenoxicam from its capsule formulations indicating the superior anti-inflammatory activity of tenoxicam. The bioavailability of tenoxicam was determined using an HPLC assay, where the pharmacokinetic parameters were determined using rabbits plasma. A good correlation was found between the percentage inhibition in edema activity and the peak plasma concentration as a measure of drug absorption where the correlation coefficient was found to be 0.928