Praziquantel effect on eosinophil cytotoxicity and humoral immune response in murine schistosomiasis mansoni

ABSTRACT

Praziquante [PZQ] is a highly effective antihelmintic drug against all S. mansoni development stages especially cercariae adult worms. Recent reports have indicated that there is a synergy between PZQ treatment and both humoral and cell mediated immune responses in experimental animal models of schistosomiasis. Therefore, this work was carried out to study the effect of PZQ on some immunological aspects of murine S. mansoni infections after in vivo PZQ treatment. The in vivo study was performed on 4 different groups of male CDI mice, including normal mice as a control group, normal mice given PZQ, infected mice and finally infected mice given PZQ 7 weeks post infection. Immunological studies revealed a significant enhancement of splenocyte antibody forminy capacity as well as raised specific anti S. mansoni antibody tite, 7 days post PZQ administration. In addition, the enhanced antibody dependent eosinophil cytotoxicity against S. mansoni schistosomula due to infection was retained after PZQ treatment