Carcinogenesis of mouse submandibular salivary gland using DMBA implant

ABSTRACT

Carcinogenesis of 35 ddy male mice subtmandibular salivary glands were attempted; using implants of a 1 mg [2 mm] prepared pellets of the potent chemical carcinogen 9, 10-dimethyl-1, 2-benzanthracene [DMBA] dry powder without a vehicle or carrier. This method appeared to be easy, fast and effective. Within a period ranging from 7-14 weeks; twenty animals developed epidermoid carcinoma [two of them developed squamous cell carcinoma of covering skin as well], and two animals developed mixed tumors [pleomorphic adenoma like tumor] but neither adenocytic carcinoma nor sarcoma were found, the results were adequacy discussed