Therapeutic modulation of praziquantel on the renal functions among Egyptian bilharzial pregnant patents

ABSTRACT

This study included 66 women, 18 normal and normal pregnant women as negative controls, and 48 patients classified into four groups. Group 1 included pregnant-dependent bilharziasis patients. Group 2 included non-pregnant-dependent bilharziasis patients. Group 3 included pregnant bilharziasis patients receiving therapy treatment. And group 4 included non-pregnant bilharzial patients receiving therapy. The groups were subjected to a battery of renal function tests. Two-three months after antischistosomal therapy, these renal functions were reassessed. All renal function parameters, urea, uric acid and creatinine, were found to be significantly elevated above normal values due to pregnancy either in healthy [controls] or illness women. The communication was extended to attenuate the severity of bilharziasis through praziquantel treatment. The results revealed that the tested renal functions were significantly reduced secondary to infection. No significant correlation existed between drug treatment and simple infection cases which gives an acute evidence that the drug tended to normalize the inhibitory action of infection particularly in chronic cases, where there was a sharp decline in its concentration, but still slight higher than control normal levels. It was concluded that a part of the selected drug was excreted through the kidney, but the main site of its action was excreted through the liver