Extraction-spectrophotometric determination of prazosin hydrochloride with palladium [II]

ABSTRACT

The described spectrophotometric determination of prazosin hydrochloride [PZH] involves the extraction of the PZH-Pb [II] complex from an acetate buffer solution pH 6.0 into a chloroform layer. The absorbance of the extracted solution is measured at 420 nm. The molar absorptivity of the complex is 2.1 x 103 l mol-1 cm-1 at 420 nm. The effects of pH [4-10], Pb [II] chloride concentration and shaking time were studied. The ratio of prazosin molecules to palladium ions in the colored complex was found to be 1 1. Finally, a procedure for the determination of PZH in pure form or in pharmaceutical preparations is recommended. The method is selective, sensitive and accurate