Immunological study of autotransplantation and partial splenectomy after traumatic rupture of the spleen

ABSTRACT

Due to the settled risk of the so called over-whelming post splenectomy Infection reported in both children and adults, which may represent a life-long risk and caused mainly by bacteria, we aimed to establish a spleen-preserving operative procedure which could be easily done when partial splenectomy is not possible, and we aim to focus light on the importance to preserve the spleen as an immnnological valuable organ. The levels of humeral immunity, mainly IgM was found to reduce after total splenectomy while its mean value increased after partial splenectomy or autotransplantation. Changes of IgG were not marked in asplenics in both children and adults [2.086 dropped to 1.700 gm/L and 2.063 to 1.675]. The phagocytic activity also decreased in asplenic subjects very significantly [76.5 to 57.7 for children and 79.2 to 63.2 for adults]. Tuftsin value was reduced in asplenics [2.17 to 2.11 mg/ml]. All these parameters were not affected in eusplenic operated subjects: