Correlation of physiological stimulants of gastric secretion to the development of different types of gastric stress ulcers in male albino rats

ABSTRACT

Restraint, cold restraint, and water immersion stress were applied to pylorically ligated male albino rats in half hourly increasing duration [0.5-3.0 h]. All models of stress tested produced gastric ulcers, the indices of which were significantly correlated with the increased duration of stress exposure, with the increased gastric mucosal histamine, with the increased serum gastrin, and with the increased total acidity and proteolytic activity of gastric juice. The significant correlation between gastric mucosal histamine and serum gastrin supports a common mediator hypothesis for the former. Increased plasma epinephrine and norepinephrine correlated with the decreased volume of gastric secretion supporting decreased mucosal blood flow as a pathophysiologic factor while hypoglyceamia could not be considered as a vagal stimulant except with cold restraint since the other models showed hyperglyceamia