Immunogenicity of recombinant hepatitis B vaccine in Iranian neonates: high frequency of unresponsiveness independeut of the carrier state of mothers
IJMS-Iranian Journal of Medical Sciences. 1995; 20 (3-4): 87-92
in English
| IMEMR
| ID: emr-37438
ABSTRACT
Immunogenicity of a recombinant hepatitis B vaccine was evaluated in a number of Iranian neonates. Of 1176 neonates vaccinated with triple doses of the vaccine at 0, 1 and 6 months, 7.4% failed to respond and did not develop a protective titer of anti-HBs antibody [>/= 10 IU/1]. Titration of anti-HBs antibody allowed classification of both responder and non-responder vaccinees into negative or borderline non-responders and low, intermediate or high responders, respectively. Unresponsiveness to the vaccine was similarly represented in both male and female vaccinees. HBs antigen was negative in all responder and non-responder neonates tested and their mothers, suggesting lack of correlation between unresponsiveness of the neonates to recombinant HBs antigen and the carrier status of the mothers
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Infant, Newborn
/
Vaccines
/
Vaccines, Synthetic
Language:
English
Journal:
Iran. J. Med. Sci.
Year:
1995
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