effects of mixed ligand of cobalt [II] on the CNS and secondary metabolism

ABSTRACT

Mixed ligand complex of cobalt[II] with glycinate ion [gly] and trimethyl amine [tma], Co[gly]2 [tma]2], has been isolated from aqueous medium. Characterization of the complex was carried out by elemental analysis, solubility, thin layer chromatography, molar conductance, magenetic susceptibility and infrared spectral measurment. The biological effect of this complex on albino mice was studied through determination of its toxicity, measuring its analgesia and negative geotaxis and its metabolic effects. Co[gly]2 [tma]2 showed an increase in blood glucose and cholesterol and decrease in heart protein. This new complex showed some biological effects, especially its analgesia and negative geotaxis effects beside the different metabolic parameters