Effect of molsidomine on trace metals in gentamicin induced nephrotoxicity in rats

ABSTRACT

This study was designed to determine the changes in trace metals after gentamicin renal injury. Rats receiving gentamicin [100 mg/kg/ day IM for 7 days] showed deterioration in renal function. Renal proximal tubular necrosis and an elevation in serum and renal cortical tissue of copper levels while the corresponding levels of zinc were depressed. The use of molsidomine can attenuate those changes in trace metals but failed to correct the deterioration in renal function or the histopathological changes. These results suggest that the alterations in trace metals seem not to be a good indicator of gentamicin nephrotoxicity