Detection of cellular and humoral markers [IL-2,IFN-8 and IgE] in sera of patients with urinary schistosomiasis

ABSTRACT

This work aimed to determine the role of cellular immune response [IL-2 and IFN-gamma] and specific humoral IgE in protective immunity in human urinary schistosomiasis, as a function of both age and infection intensity including examination of the changes in immunoresponsiveness following curative therapy. The study revealed that IL-2, IFN-gamma level were higher in all patients compared with the normal control group and the levels were higher in lightly infected groups than heavily infected ones with no respect to age. IgE levels showed higher values compared with normal individuals and IgE levels were higher in children groups than in adults regardless of the intensity of infection. IL-2, IFN-gamma and IgE levels were higher in patients with mixed S. mansoni and S. hematobium infections than monoinfected patients. Follow up of patients 2, 4 and 12 months after praziquantel treatment showed that the level of IL-2 and IgE fell back to normal values after 4 months while IFN-gamma remained high. IL-2, IFN-gamma and IgE were raised once more after 12 months