Selective histamine blockade in asthma: the effect of astemizole on resting bronchial tone and exercise induced broncho-constriction
Journal of the Faculty of Medicine-Baghdad. 1995; 37 (1): 51-59
in English
| IMEMR
| ID: emr-37725
ABSTRACT
The orally active histamine HI-blocker astemizole was investigated for its effect on resting bronchial tone and exercise-induced broncho-constriction in 20 asthmatic patients by a double-blind placebo-controlled study. Astemizole produced acute bronchodilation with an average 16% improvement in FEVl by 3 hours. After exercise challenge, astemizole partially inhibited exercise induced bronchoconstriction. These results suggest that asthmatic patients have augmented background resting histamine tone which is reversible by Hl blockade
Search on Google
Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rest
/
Asthma
/
Asthma, Exercise-Induced
/
Bronchi
/
Bronchial Diseases
/
Astemizole
/
Constriction, Pathologic
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J. Fac. Med.-Baghdad
Year:
1995
Similar
MEDLINE
...
LILACS
LIS