Pattern of disaccharidases in chronic diarrhoea and malabsorption
Journal of the Faculty of Medicine-Baghdad. 1995; 37 (2): 275-285
in English
| IMEMR
| ID: emr-37752
ABSTRACT
Disaccharide-splitting enzymes were analyzed in the jejunal mucosae of 48 patients suffering from chronic diarrhoea and/or malabsorption, and the results were compared to those of 11 controls. Four [36.4%] of the controls were found to have partial lactase deficiency with a mean ratio of sucrase to lactase activity of 54.8 [SEM +/- 60.06] Significant reduction in the disaccharidases [lactase, sucrase, maltase, and isomaltase] were observed in patients with celiac disease and primary intestinal lymphoma; other groups exhibited variable affection in all disaccharidasas. High incidence of hypolactasia in these patients is the net results of both genetic influence on lactase activity and as a consequence to mucosal injury. It is suggested that further studies should be carried out using intestinal biopsy and direct enzyme assay in a large number of healthy adults
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Sucrase
/
Chronic Disease
/
Beta-Galactosidase
/
Diarrhea
/
Alpha-Glucosidases
/
Jejunum
/
Malabsorption Syndromes
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
J. Fac. Med.-Baghdad
Year:
1995
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