study on serum triglyceride and lipoproteins cholesterol in coronary heart disease patients

ABSTRACT

Sera obtained from 42 patients of myocardial infarction, 28 of unstable angina and 25 healthy control subjects were assayed for total triglycerides, cholesterol, LDL cholesterol [LDL-C], HDL Cholesterol [HDL-C] and VLDL Cholesterol [VLDL-C]. The level of Cholesterol was also determined among the sub-fractions of HDL. The levels of total triglycerides, Cholesterol, LDL-C and VLDL-C were significantly raised in both groups of patients. Total high density liporotein Cholesterol was low in patients, which was highly significant in HDL[2]-C and not in HDL[3]-C. These results suggest that serum lipids are directly correlated with the severity of coronary heart disease [CHD]. Total Cholesterol when measured in major lipoprotein classes and further partitioned into subfractions, increase their sensitivity, specificity and hence their predictive value as sensitive markers for the assessment of CHD risk