Serum myoglobin: a marker for successful thrombolytic therapy in acute myocardial infarction

ABSTRACT

The material of this study comprised 30 patients with acute myocardial infarction as a test group and 10 normal cases with matched age and sex as a control group. The patients were divided into two groups. Group I, 15 patients [10 males and 5 females] with ages ranging between 41-72 years with a mean of 52.8 + 10.04 years, and group II, 15 patients [9 males and 6 females] with ages ranging between 50-62 years with a mean of 55.7 + 3.68 years. Both groups I and II received the usual treatment of myocardial infarction, in addition group II patients received IV streptokinase as a thrombolytic therapy. All patients were subjected to thorough history and full clinical examination, the serum myoglobin levles were determined using the immunoturbidimetric method, serum CPK and SGOT, fasting and postprandial blood sugar and serum creatinine. A 12 leads ECG was done for every patient on admission, just after therapy and 6 hours after therapy [for streptokinase group]. This study illustrates the values of immunoturbidimetric assay of serum myoglobin as a sensitive marker for early diagnosis of acute myocardial infarction and follow up of thrombolytic therapy for these patients