Some haematological studies on marshal in white rats

ABSTRACT

Forty rats were used to investigate the effects of marshal insecticide on hemogram, bone marrow and blood coagulation. Treated rats were fed on a ration containing 500 ppm marshal for 3 weeks. Blood and bone marrow samples were taken weekly and subjected to examination of RBCs and WBCs count, Hb concentration, PCV, platelet count, fibrinogen, PT and APTT. In addition to determination of M/E ratio in the bone marrow. The same tests were done in the control group. A marked decrease in RBCs count, Hb concentration and PCV was noted with development of microcytic hypochromic anaemia. Bone marrow showed a marked increase in the M/E ratio. A significant decrease in platelet count was recorded while fibrinogen values, PT and APTT were significantly increased throughout the experiment