Impaired flow-dependent coronary vasomotor reactivity of infarct-related artery after coronary angioplasty

ABSTRACT

The aim of this work is to study the vasomotor reactivity of infarct- related artery after coronary angioplasty in patients with acute myocardial infarction [AMI]. 20 patients with anterior myocardial infarction were included in the study. Thrombolytic therapy was administered to all patients. The patients underwent coronary angiography there were two or five weeks after thrombolytic therapy. According to coronary angiography, there were two groups of patients, group I Included 10 patients who had residual stenosis >50% after thrombolysis and underwent PTCA for infarct-related artery and group II Included 10 patients who had residual stenosis <50% after thrombolysis and were not candidates for PTCA. Intracoronary injection of papaverine [PAP] through diagnostic and guiding catheter followed by nitroglycerine [NTG] infusion after 5 minutes. Automatic vessel-segment diameter was detected in end diastolic frames. It is concluded that there was a significant decreased vasomotor reactivity to injection of papaverine after PTCA in patients who received thrombolytic therapy and these changes were not significantly correlated to residual stenosis after angioplasty