Changes in the metabolism of collagen in uremic patients without and after hemodialysis

ABSTRACT

The aim of the present work is to throw some light at the metabolism of collagen regarding both synthesis and degradation in uremic patients without and after hemodialysis. Serum procollagen III peptide and hydroxyproline were studied in twenty chronic renal failure [CRF] patients [ten hemodialysed and ten non dialysed] and ten normal control subjects. Levels of serum PIIIP showed a significant elevation [p< 0.01] in uremic cases [both non dialysed and dialysed groups] when compared with the normal control group. Levels of serum hydroxyproline showed a significant elevation in non dialysed CRF patients [p< 0.01] when compared with the normal control group. These returned to normal after hemodialysis