TSH, T3 and T4 serum levels in albino rats after intraperitoneal administration of khat extract for 5 days

ABSTRACT

The present study was conducted on normal adult albino rats of both sexes. Their body weight ranged between 200 and 250 gm the experimental animals received 0.2 ml Khat extract by intraperitoneal injection for 5 successive days. In the control male group the mean. Thyroid stimulating hormone [TSH] serum level was 0.766 +/- 0.273 micro IU/ml and was significantly increased to 1.66 +/- 0.81 micro IU/ml in the experimental group. In the control non-pregnant and pregnant female groups the mean TSH serum levels were 0.85 +/- 0.39 micro IU/ml and 1.11 +/- 0.41 micro IU/ml respectively and were significantly increased to 1.98 +/- 0.53 micro IU/ML and to 2.73 +/- 0.37 micro IU/ml in the corresponding experimental groups. In the control male group the mean Triiodothyronine [T3] serum levels was 46.17 +/- 4.81 ng/dl and was significantly increased to 61.17 +/- 649 ng/dl in the experimental group. In the control non-pregnant and pregnant female groups the mean T3 serum levels were 43.67 +/- 3.73 ng/dl and 53.83 +/- 3.53 ng/dl respectively and were significantly increased to 62.67 +/- 7.34 ng/dl and to 70.67 +/- 7.97 ng/dl in the corresponding experimental groups. In the control male group the mean. Thyroxine [T4] serum level was 3.32 +/- 0.38 micro gm/dl and was significantly increased to 4.22 +/- 0.49 micro mg/dl in the experimental group. In the control non-pregnant and pregnant female group the mean T4 serum level were 3.17 +/- 0.43 micro gm/dl and to 4.93 +/- 0.27 micro m/dl in the corresponding experimental groups