Monoclonal protein and its complication in chronic lymphoproliferative disorder [CLD]

ABSTRACT

Investigations of monoclonal proteins and Bence-Jones globulin in serum and urine were carried out in 15 normal subjects and 49 patients with chronic lymphoproliferative disorders divided into a] 10 cases with multiple myeloma, b] 9 cases with Waldenstrom's macroglobulinemia, c] 12 cases with chronic lymphoyctic leukemia, d] 9 patients with Hodgkins distyping of Bence-Jones and monoclonal protein were studied by the immunofixation technique. Immunoglobulins and the light chain proteins [kappa and lambda] as well as the determination of urea and creatinine were also studied in five groups of patients as compared to control. It is concluded that, in multiple myeloma and Waldenstrom's macroglobulinemia, some patients were characterized by light chain diseases, due to the high detection of light chain globulin in both serum and urine with the evidence of abnormal proliferating plasmacytes. In addition, the occurrence of renal dysfunction or insufficiency could be demonstrated among many patients of both groups as compared to Hodgkin's and non Hodgkin's lymphoma