Dopaminergic receptor regulates catecholamine release from perfused adrenal medulla
New Egyptian Journal of Medicine [The]. 1995; 12 (3): 365-369
in English
| IMEMR
| ID: emr-38831
ABSTRACT
Nicotinic drug is a potent secretogogues for catecholamine from bovine adrenal glands perfused with oxygenated Locke's buffer. However, apomorphine, I IIM, [the dopaminergic agonist] markedly inhibit this catecholamine release by about 40%. Haloperidol 0.5 muM, [the dopaminergic antagonist] reversed the inhibitory effects of apomorphine. These data strongly suggested that, as in the cat, the bovine adrenal modulates the catecholamine cell contains a dopaminergic receptor that modulates the catecholamine secretory process triggered by stimulation of the nicotinic cholinergic receptor. This dopaminergic receptor might be involved in a sympathoadrenal cooperative mechanism
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Catecholamines
/
Adrenal Medulla
Language:
English
Journal:
New Egypt. J. Med.
Year:
1995
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