Microcirculation profile in benign and malignant prostate tissue immunologic study

ABSTRACT

Microscopic vascularity was studied in 15 cases of benign prostate tissue and 15 cases of prostatic carcinomas. H and E stain and immunohistochemistry by marking the vascular endothelial cells with antibodies to factor VII related antigen were used to detect microvessel profiles in tissue sections. In benign prostate tissue the capillaries are more dense near hyperplastic gl and s than cystic one and in perigl and ular stroma than the interlobular one. The data demonstrated the increased density of capillaries with more irregularity in prostatic carcinomas when compared with benign prostate tissues, also the capillaries have tiny lumens and irregular angular shape. Capillary densities were variable from tumor to tumor