Role of colonic bacteria in the pathogenesis of urinary tract infection

ABSTRACT

160 children aged between 2-12 years [60 circumcised males and 100 females] with clinically suspected urinary tract infection [UTI] were examined. Culture for urine stool and anogenital swab were done. Evaluation of personal habits and local hygiene of anogenital area for every case assessed using suitable questionnaire. Bacteriological examination of urine showed that 86.9% of the cases had positive urine culture and significantly bacterial count with predominance of E. coli 53.2% of cases, Klebsiella in 17.3% and Proteus 8.6%. The other organisms represent 20.8% of the total cases. Pathogenic organisms were isolated from stools in 45% of cases. Swabs of anogenital region revealed that 38.8% of cases had a positive swab culture. Matching between culture of urine, stools and anogenital region found that serotyping of E. coli stains are the same in 20 cases. Klebsiella and Proteus isolated from urine, stools and perianal region had the same biochemical reaction in 13 cases. 6.1% of the cases had local hygienic cause related to anogenital region. Thus, it is advisable to follow a strict hygienic measures for carring of anogenital region and for prevention of contamination and ascending urinary tract infection