Catecholamine induced myocardial necrosis an experimental study with potential clinical implications [part 1]

ABSTRACT

Myocardial necrosis does not imply only coronary artery disease. It might be due to accelerated O2 consumption due to heightened sympathetic activity with consequent depletion of ATP and creatine phosphate. This study induced myocardial necrosis in rats through excessive beta-adrenergic stimulation using isoprenaline [Iso] infusion, aiming at establishing the validity of an experimental model. 54 adult albino rats with an average weight 115 g were studied. The animals were divided into a control group [10 rats] and Isop. treated group [44 rats]. In conclusion, isoprenaline could induce myocardial necrosis in rats in a dose dependent fashion without ligating the coronary arteries. An attempt has been made to draw analogy between necrosis lesions that IV catecholamines could induce in experimental animals and possible similar lesions that excessive and ogenous catecholamines can produce in human beings