value of immunohistochemical detection of p53 protein in endometrial hyperplasia and carcinoma as a diagnostic and prognostic marker

ABSTRACT

50 cases of formalin-fixed paraffin embedded tissue sections of endometrial lesions representing 21 endometrial hyperplasia [7 simple, 9 complex and 5 complex atypical] and 20 endometrial carcinomas were studied for the detection of P53 protein expression using the ABC immunohistochemical method. 9 out of the 29 cases [30.1%] of endometrial carcinomas showed positive expression for the P53 protein. On the other h and, P53 protein could not be detected in all the cases of endometrial hyperplasia. No statistically significant relation was found between P53 protein expression and the patient's age or the tumor grade. These findings may indicate that P53 mutation is late event in endometrial tumorigenesis