Effects of the converting enzyme inhibitor enalapril on the metabolic abnormalities associated with Theophylline intoxication

ABSTRACT

The effects of enalapril administration in a dose of 5 mg/kg body weight on the metabolic abnormalities associated with theophylline acute intoxication and overmedication was studied in rats. The results showed that single dose administration of enalapril had provided a partial protection against acute theophylline-induced metabolic effect. A lesser changes were occurred in all measurable variables in the combined treatment group of animals. Repeated enalapril dosages were capable to prevent the development of such metabolic abnormalities. It seems that repeated enalapril administration could be beneficial in preventing the metabolic abnormalities associated with theophylline intoxication