Pakistan Journal of Pharmacology. 1995; 12 (1): 51-56
in English
| IMEMR
| ID: emr-39129
ABSTRACT
The analgesic activity of epicoprostanol, the major sterol of ambergris was investigated in male mice, using the hot plate method. Epicoprostanol [1, 10, 100 mg/kg i.p.] significantly increased the hot plate reaction times measured at 60 min post injector. P. chlorophenol alanine which depletes central 5 - HT, only inhibited the antinociceptive activities of 1 and 10 mg epicoprostanol, whereas DSP -4, a neurotoxin of central noradrenergic, the nor adrenergic and serotonergic systems may also be involved in this activity of epicoprostanol
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Sterols
/
Analgesics
Language:
English
Journal:
Pak. J. Pharmacol.
Year:
1995
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