Serum lipid profile and lipoprotein [a] in patients with chronic renal failure [CRF] under different methods of therapy

ABSTRACT

Eighty subjects [60 patients with chronic renal failure [CRF] under different method of therapy, in addition to 20 healthy normal control subjects] were included in this study. They were subdivided into the following groups. Group I included 20 normal health subjects as controls. Group II included 20 patients of CRF under conservative treatment. Group III included 20 patients of CRF under haemodialysis [HD]. Group IV included 20 patients of CRF under chronic peritoneal dialysis [CPD]. For all groups serum lipid profile was done including serum triglycerides total cholesterol, HDL-C, LDL-C, HDL-C/ LDL-C ratio, ApoA, ApoB, ApoA/ApoB ratio and Lipoprotein [a] [Lp[a]], And we get the following results: There was a significant increase in serum triglycerides in different groups of CRF under different methods of therapy [conservative treatment, haemodialysis and chronic peritoneal dialysis] [P < 0.001 for all]. There was a significant increase in total serum cholesterol in patients with CRF under chronic peritoneal dialysis [P < 0.001], but non significant changes in the conservative treatment [P > 0.05] and haemodialysis [P > 0.05] groups. There was a significant decrease in HDL-C in all the studied groups of CRF under different methods of therapy [P< 0.001 for all]. There was a significant increase in LDL-C in CRF patients under CPD [P < 0.001, and non significant chnages in its level in the conservative treatment and HD groups [P > 0.05 for both]. There was a significant decrease in HDL - C/LDL-C ratio in all groups of CRF under different methods of therapy [conservative treatment [P < 0.001], HD [P < 0.01] and CPD [P<0.001]]. There was a significant decrease in ApoA in all groups of CRF under different methods of therapy [P < 0.001 for all]. There was a significant increase in ApoB in CPD group [P < 0.001] and non significant changes in both the conservative treatment and haemodialysis groups [P > 0.05 for both]. There was a significant decrease in ApoA /ApoB ratio in all groups of CRF under different methods of therapy [P < 0.001 for all]. There was a significant increase in serum LP [a] in all groups of CRF under different methods of therapy [P < 0.001 for all]. The level of LP [a] in both the HD and the CPD groups both before and after dialysis was non significantly changed. There was significant negative correlation between Lp [a] and both of HDL - C / LDL -C ratio [P < 0.05 for all groups] and Apo A /Apo B ratio [P < 0.05 for all groups]. There was a significant Positive correlation between serum level of Lp [a] and the duration of treatment for conservative treatment group [P < 0.05], and non significant changes in both HD and CPD groups [P > 0.05 for both]. There are changes in serum lipid profile and Lp [a] in CRF patients under different methods of therapy which share with other factors for increasing succeptibility to atherogenecity in these patients