Diclofenac sodium in renal and ureteral colic: a double-blind comparison with hyoscine N-butyl bromide

ABSTRACT

The analgesic effects of diclofenac 75 mg IM and hyoscine N- buty1 bromide 20 or 40 mg or IV were compared in a randomized double-blind study, in 422 patients reporting moderate to severe pain due to renal or ureteral colic. Patients evaluated their pain intensity and pain relief at 0 [baseline], 15, 30, 45 minutes and hourly for 3 hours. A significant difference [p < 0.05] was found between the two groups with respect to pain intensity difference [PID], mean pain relief and onset time of analgesia. Diclofenac sodium was significantly [p < 0.05] superior to hyoscine N buty1 bromide in pain relief. Significantly [p < 0.05] fewer patents required a second dose in diclofenac sodium treated group compared to the other spasmolytic group. The dose and the route of administration of hyoscine N buty1 bromide had no significant [p > 0.05] effect on the proportion of patients with complete relief. These results confirmed that diclofenac sodium can be safely used in the management of acute renal and ureteral colic as an alternative to hyoscine N buty1 bromide