Experimental trials in treatment of chronic Salmonellosis and carrier state with bilharzial infection

ABSTRACT

In mice, the histopathologic sequences of changes in bilharzial lesions after application of certain antibilharzial drugs are studied. It has become clear that the resulting dense fibrosis may be responsible for the increased portal hypertension observed after treatment. The use of septrin, as antibilharzial drug, has to be reserved only for decompensated cases. In cases with double infections by bilharziasis and S. paratyphi A, carriers and resistant cases, ambilhar and astiban have an antisalmonella action even with low dilution. Astiban and ampicillin are the combination-therapy of choice to mice doublyinfected by bilharziasis and salmonellosis. They rapidly sterilize the liver and spleen of mice as well as the cuticle and caeca of adult worms as detected by culture. Being a safe combination, they produce minimal cytologic changes in the affected organs