Characterization of Hodgkin's disease cells in culture [2] Reed strenberg cells and macrophages

ABSTRACT

The Hodgkin's mononucleated giant cells in culture were proliferating with over-riding, cross over and clumps in suspension, intensified their malignant nature ending in the R.S. non proliferating multinucleated end cells. They were derived from the non-phagocytic supportive cells [reticular cells] as they were non-phagocytic for opsonized dyed yeasts, negative for E resetting. Fc receptors and complement receptors as well as non-specific esterase. The macrophages behaved normally in culture but they proliferated in conditioned medium. They are not the origin of R.S. cell