Physical and dissolution characteristics of ibuprofen and diclofenac sodium tablets made with polyacrylamide

ABSTRACT

Tablets containing polyacrylamide were investigated with regard to their physical st and ards and release profile. The use of this polymer gave tablets of good mechanical property especially with Avicel regardless of both type of the medicament and concentration of the polymer. The tablets disintegrated very rapidly only at low concentrations of the polymer. In addition, a sustained release behavior was obtained depending upon the solubility of the drug and type of diluent. The tablets containing Avicel released about 47% and 59% diclofenac sodium and ibuprofen, after about 6 hours employing 20% polymer concentration. On the other h and, at least 30% polymer concentration was required to produce such effect for tablets containing spray dried lactose. Generally, most of tablets showed a typical square root of time release according to Higuchi equation