Plasma and tissue CAMP in experimental acute uremia in rats

ABSTRACT

Uraemia was induced in rats by bilateral ureteral ligation. 3',5'-cyclic adenosine monophosphate [CAMP] concentration was estimated in the plasma and tissues [brain, liver, kidney and adrenals] of control and uraemic rats. Cyclic AMP in the plasma, brain, kidney and adrenals was markedly increased in uraemic rats whereas, liver CAMP did not change significantly. The increased plasma CAMP was suggested to originate from these tissues. The mechanisms and pathophysiological significance of the increased CAMP in tissues were discussed