Synthesis of some new 9-substituted acridines of possible Antimicrobial activity
Alexandria Journal of Pharmaceutical Sciences. 1996; 10 (2): 105-109
in English
| IMEMR
| ID: emr-40280
ABSTRACT
A series of 9-substituted acridines has been synthesized utilizing 3-[9-acridinyl] propanoylhydrazine, 9-[4-aminophenyl] acridine [II] and 9-chloromethylacridine [III] as starting materials. The hydrazones Ic and Id as well as the Schiff bases IIa-IIc were produced via condensation of the acid hydrazide Ib or the amine II with different aldehydes. The acid hydrazide Ib was also reacted with some acid anhydride to afford the pyridazinone derivatives Ie and If. In addition, 9-chloromethylacridine [III] was reached with glycine, sulfanilamide or sulfadiazine to give the corresponding N-alkylated derivative IIIa-IIIc. The structure of the synthesized products was substantiated by spectroscopic data and elemental analyses. Some of the prepared compounds were found to possess antimicrobial activity
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Acridines
Language:
English
Journal:
Alex. J. Pharm. Sci.
Year:
1996
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