Effect of bromocriptine [parlodel] on hormonal profile of the adult male albino rats with special reference to changes in histologieal structure of the testes

ABSTRACT

Bromocriptine [Parlodel] is used for treatment of hyperprolactinemia in men, prolactin related hypogonadism [oligospermia-loss of libido, impotence]. It acts as stimulator for dopamine receptor. In this experiment, 60 adult male albino rats were divided into 3 equal groups. The first kept as control, injected with normal saline. Both the second and third groups were injected once daily with intramuscular [I/M] doses of 10 and 20 mug of bromocriptine dissolved in 0.4 ml of distilled water, respectively. Blood samples were collected after one and two weeks from treatment and plasma were separated and stored at -20C for hormone assay using RIA technique. The results indicated significant increase in testes weight, decrease in plasma levels of prolactin and testicular histamine concentration; while LH, FSH and testosterone were increased significantly with increasing the dose and time of treatment. The histological findings of the testes revealed changes including edema, exploration of seminiferous epithelium which increased after administration of the larger dose [20 mug] for two weeks