Zuclopenthixol versus haloperidol in the initial treatment of schizophrenic psychoses, affective psychoses and paranoid states; a controlled clinical trial

ABSTRACT

An open-ended controlled clinical trial was carried out on forty-nine patients with mania, acute psychoses or exacerbation of a chronic psychosis to compare zuclopenthixol acetate with haloperidol to determine the efficacy and adverse effects during a six day trial period. Both zuclopenthixol acetate and haloperidol were equally effective in patients with acute psychosis, exacerbation of chronic psychosis and in mania. Zuclopenthixol acetate produced a greater degree of sedation in the initial phase of treatment and caused fewer extrapyramidal side effects than haloperidol,and the patients treated with zuclopenthixol acetate needed less anti-parkinsonian treatment