CSF cytokines, nitric oxide and prostaglandins in diagnosis and pathophysiology of childhood CNS leukemia and lymphoma
Assiut Medical Journal. 1996; 20 (5): 73-86
in English
| IMEMR
| ID: emr-40454
ABSTRACT
To clarify the role of cytokines, nitric oxide [NO] and prostaglandin- E2 [PG-E2] in diagnosis and pathogenesis of infiltration of central nervous system [CNS] in cases with leukemia and lymphoma, the levels of these indices in the cerebrospinal fluid [CSF] of those children were determined. Their levels were correlated with other laboratory studies of CSF and clinical criteria. This study included twenty- seven children with acute leukemia [twenty with acute lymphoblastic leukemia [ALL] and seven with acute myeloid leukemia [AML]] and fifteen with non- Hodgkin's lymphoma [NHL]. Clinical evidence of CNS involvement was present in seventeen patients with acute leukemia and seven cases with NHL. The study revealed significantly elevated levels of two types of cytokines [TNF-alpha, IL-6] NO and PG-E2 in CSF of children with acute leukemias and lymphoma compared with control group [children with tension headache or meningism]
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Lymphoma, Non-Hodgkin
/
Leukemia
/
Leukemia, Myeloid
/
Central Nervous System
/
Child
/
Prostaglandins
/
Cytokines
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/
Lymphoma
/
Nitric Oxide
Limits:
Humans
Language:
English
Journal:
Assiut Med. J.
Year:
1996
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