Effect of eradication of Helicobacter pylori, using omeprazole and amoxicillin, on the level of serum gastrin, somatostatin and secretin in Egyptian patients with duodenal ulcers

ABSTRACT

Forty-three patients with duodenal ulcer [DU] diagnosed by endoscopy and fifty-one patients with non-ulcer dyspepsia [NUD] were included in this study. The diagnosis of H. pylori [HP] was performed using urease test and culture of four biopsies from the antrum and corpus. Gastrin was measured by RIA, SO and SEC by ELISA. DUs patients received omeprazole [20 mg/day] for four weeks and amoxicillin [500 mg 3 times/day] for two weeks and follow up was performed for 23 patients with DUs after one month. It was concluded that patients with DUs had higher levels of G and lower levels of SO and SEC than patients with NUD. HP seems to be responsible for increased G and reduced SO in patients with DUs and its eradication led to significant reduction of G and increase in SO with consequent reduction in acid secretion