Long-term fate of gastrocystoplasty and enterocystoplasty: an experimental study

ABSTRACT

This study was carried out on 100 rats with an average weight of 250 grams. They were divided Into 5 groups 20 non-operated rats served as a control group, while 20 rats each underwent sham procedure, gastrocystoplasty, ileocystoplasty and sigmoidocystoplasty. All operations were performed with microsurgery by a technique which is described. The rats were sacrificed 12 months postoperatively. There were no differences in serum electrolytes or renal function between the single groups. All urine cultures taken pre- and postoperatively were sterile. Prominent histopathologic changes were observed in the transplanted gastric and intestinal tissues and in the adjacent bladder wall. Possible aetiologies are discussed, but the actual aetiology and the potential for malignant progression of these lesions are unknown. Thus further studies with longer follow-up are warranted