Synthesis of some novel derivatives of-1,4-benzoxazepine-3,5-diones as Anticonvulsant agents

ABSTRACT

The present investigation involves the synthesis of 1,4-benzoxazepine-3,5-dione I as a key intermediate for some biological derivatives comprising II and III where the compounds IIa-f were prepared by applying Mannich conditions to I. On the other hand, the compounds III a-g were synthesized by condensation of I with different aromatic aldehydes. The result of preliminary anticonvulsant testing of selected compounds is included