Synthesis of certain substituted quinolines as potential DNA complexing agents
Egyptian Journal of Pharmaceutical Sciences. 1996; 37 (1-6): 57-64
in English
| IMEMR
| ID: emr-40779
ABSTRACT
Two series of 2,4,6-trisubstituted quinoline derivatives were prepared for potential DNA complexing activity. The first series comprises the preparation of 4-arylaminoquinoline derivatives 9-24 by amination of 4-chloroquinolines 5-8, while, the second series involves the preparation of the amide derivatives of cinchoninic acid 27-30 by amidation of 2-phenyl-4-cinchonoyl chloride 26. Three new compounds were tested for in vitor cytotoxic activity
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Quinolines
/
DNA
/
Antineoplastic Agents
Language:
English
Journal:
Egypt. J. Pharm. Sci.
Year:
1996
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