New synthesis of some 1,8 naphthyridines of possible antimicrobial activity

ABSTRACT

Some new 2,7-dimethyl-4-[p-[5-aryl-2-pyrazolin-3-yl] anilino] 1, 8-naphthyridines [4a-d] and other related products of the isoxazolines [5a-d] and the pyrimidines [6a-d] were synthesized for the purpose of antimicrobial evaluation. Some representative examples of 4b,c, 5a and 6a showed moderate activity against the growth of Bacillus subtilis, Staphylococcus aureus and Aspergillus niger