Vitamins prevention of diabetic complication: effect of vitamins C and B6 on glycosylated hemoglobin and sorbitol dehydrogenase
Egyptian Journal of Pharmaceutical Sciences. 1996; 37 (1-6): 415-422
in English
| IMEMR
| ID: emr-40809
ABSTRACT
The experiments were undertaken to assess the role of vitamin C [ascorbic acid] and vitamin B6 [pyridoxine] in relation to sorbitol dehydrogenase activity and glycosylated hemoglobin levels in sorbitol pathway linked neural and vascular dysfunction and nonenzymatic glycosylation in rats with alloxan induced diabetes. Vitamins C and B6 monotherapy were given orally to control and diabetic rats. After 30 days and 45 days of treatment, glycosylated hemoglobin levels were decreased significantly [p <0.05 to 0.001]. Sorbitol dehydrogenase activity in normal rats during vitamin C therapy were increased significantly [p <0.08 to 0.001] from 7 to 9 folds after 30 days and 45 days, respectively. In diabetic rats sorbitol dehydrogenase activity elevated about 2.5 folds. Vitamin B6 increased sorbitol dehydrogenase activity about 7 folds in normal and 3 to 2.5 folds after 30 days and 45 days, respectively, in diabetic rats. These observations together with other evidence, suggested the significant relationship between glycosylated hemoglobin, sorbitol dehydrogenase and intake of vitamin C and vitamin B6. The elevated sorbitol dehydrogenase activity associated with the previously reported sorbitol levels. These vitamins supplementation is effective in individuals with insulin-dependent diabetes mellitus [IDDM]. They may be potentially important in controlling glucose-induced nonenzymatic glycosylation of proteins and, therefore may be a preferable drugs for inhibiting glucose induced nonenzymatic glycosylation, neural and vascular dysfunction
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Ascorbic Acid
/
Pyridoxine
/
Rats
/
Vitamins
/
Glycated Hemoglobin
/
Diabetes Mellitus
/
Diabetes Mellitus, Experimental
/
Alloxan
/
L-Iditol 2-Dehydrogenase
Limits:
Animals
Language:
English
Journal:
Egypt. J. Pharm. Sci.
Year:
1996
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