Pharmacokinetic studies of SHAM capsules

ABSTRACT

Urinary excretion data of salicylhydroxamic acid [SHAM] on human volunteers were used to compute its pharmacokinetic parameters. HPLC method was used to determine drug content in urine. The study revealed that, the drug is rapidly absorbed and excreted. The absorption half life of the drug ranged between 15.2-23.2 min. While, its urinary elimination t1/2 was in the range of 23.1 to 42.2 min. The amount of the drug eliminated in urine reaches to about 75% of the oral dose administrated proving SHAM efficiency as antilithiatic drug. On the other hand, the drug is hardly detected in urine after 6 hours indicating a thorough revision of dosage regimen