Effect of a single therapeutic dose of oxytetracycline on some blood constituents and serum enzymes in sheep

ABSTRACT

A single intramuscular injection of 15 mg/kg. b.wt., of oxytetracycline chloride was gives to normal awassi rams and ewes. Blood samples were collected at 3, 6, 12, 24, 48, 72, 120 and 168 hr. after injection. Serum glucose significantly increased after 3 hr. then sustained a slight reduction until 24 hr. total plasma protein increased from 6-120 hr. Creatinine did not change. Urea and urea nitrogen levels varied according to sex. Rams have a short significant increase at 3 hr.; ewes showed a marked decrease during the first 6 hr. followed by a marked increase at 24 hr. got activity increased at 6-12 hr. and GPT activity remaining unaffected gave indication for mild temporary toxicity