Effect of long-term administration of beta-adrenergic blockers on some enzyme activity and blood criteria in rats

ABSTRACT

Daby intramzscular injection of the beta-adrenergic blockers; sotalol, propranolol and oxprenolol in doses of 10.0 and 20.0 ug/rat for one month resulted in various alterations in the activity of some enzymes and blood pictures of female rats. Sotalol hydrochloride in either dose caused highly significant increase in alkaline phosphatase, SGOT and SGPT enzyme activity, highly significant decrease in erythocytic and leucocytic counts but insignificant effect on haemoglobin content of blood. Propranolol hydrochloride in a dose of 10.0 ug/rat showed insignificant effect on alkaline phosphatase, SGOT and highly significant increase in SGPT activity. The large dose produced marked activation of alkaline phosphatase, SGPT but on significant effect on SCOT enzyme. Both doses caused highly significant decrease in red and white blood corpuscles counts and no significant effect on haemoglobin content