Changes of urinary bladder salvage preservation in muscle invading transitional cell carcinoma of urinary bladder by the use of neoadjuvant chemotherapy and radiation therapy
Medical Journal of Cairo University [The]. 1996; 64 (Supp. 3): 119-125
in English
| IMEMR
| ID: emr-42328
ABSTRACT
Based on the excellent results obtained with chemotherapy in patients with advanced transitional cell carcinoma of urinary bladder, neoadjuvant chemotherapy has been advancated t improve survival and in some cases to permit bladder conservation. Twenty nine patients with transitional cell carcinoma of urinary bladder were seen at EBGH, Jaddah Cancer, Jan 1991-1994. All patients had tumour of either T[2] or T[3] stage N[X]-N[2] MO. Patients were given 3 cycles of CMV chemotherapy with cisplatinum, methotroxate and vinblastine. Patients who attained complete are partial response were given radioation therapy. The clinical complete response rate after chemo-radiation therapy was 59% [17/29 patients]. The 2-year disease free survival rate for the complete respondent is 76% whereas for the complete responders goups a 25% 2-year survival is attained. Surgery by radical cystectomy was offered to non responders as well as to chemoradiation therapy failures. The 2-year disease free survival with preserved bladder is 41%. Complete responders after chemoradiation therapy stand a good change of disease control with bladder preservation. Radical cystectomy is the appropriate treatment if no complete response is attained after chemotherapy
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Treatment Outcome
/
Chemotherapy, Adjuvant
/
Radiotherapy, Adjuvant
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Med. J. Cairo Univ.
Year:
1996
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