a comparative histochemical and immunohistochemical study using angor counts and p53 expression as prognostic indices in ovarian epithelial tumors

ABSTRACT

In the present study, both P53 expression and AgNOR counts were assessed in epithelial ovarian tumors. P53 was consistently negative in benign cases [n =25]. Atypically proliferate tumors were negative, except for two cases which showed atypia [n =8]. In contrast, 63.2% [n =24] of malignant cases expressed P53 in either focal or diffuse patterns. P53 showed a significant linear association between the three studied groups. A significant linear association was also found between P53 expression and both grade and clinical outcome of epithelial ovarian carcinomas. No significant linear association was found between P53 expression and the clinical stage. Using the simple silver staining technique, a significant difference was found between AgNOR counts of both benign and atypically proliferate tumors on one h and and malignant tumors on the other hand. A significant direct correlation was also seen between AgNOR counts and both grade and stage of epithelial ovarian carcinomas. In addition, a significant difference was seen between responders and partial responders on one side and non-responders on the other side