Sexual maturation in renal transplant girls

ABSTRACT

Sexual maturation was evaluated in 18 living related donor renal transplant girls receiving a combination of immunosuppressive treatment including cyclosporine A, prednisolone and azathioprine and were followed for 2 years post-transplant. All transplant girls underwent clinical evaluation, endocrinologic evaluation and measurement of height, Tanner stage and bone age. The results showed that height SDS in 38.9% was greater than 2 SD below the mean for age. Pure retarded sexual maturation was observed in 22% of boys. There was no significant correlation between any of the maturation parameters and the duration of uremia, serum oestradiol, prolactin, gonadotrophins hormones, interval since transplantation, age at transplantation. Dialysis duration was significantly correlated with maturation parameters