Influence of different pesticide dethamethrin concentrations on the phospholipid composition of carp erythrocyte plasma membrane

ABSTRACT

In this study, the effect of different concentrations [0.1, 1.2 and 4 ppm] of deltamethrin on the carp erythrocyte plasma membrane was examined following exposure time 48 and 96 hours. The results showed that, the deltamethrin pollutants significantly [P < 0.01] led to decrease of phosphotidyle ethanolamine [PE], phosphoglycerides [PG] and phosphatidic acids [PA] and high concentrations of it led to eliminates the phosphatidic acids and cardiolipin [CL]. Also, deltamethrin pollutant brought about marked difference in the fatty acid patterns of the phospholipids erythrocyte plasma membrane. The increase concentration leads to an increase in the level of saturated fatty acids primarily palmitic [16 0] and stearic acid [18 0] as well as in the level of polyunsaturated fatty acids [PUFAs], especially arachidonic acid [20 4 n-6]. Of monosaturated fatty acids [MUFAs] palmitoleic acid [16 1 n-7] and oleic acid [18 1 n-9] did not increased significantly. At the same time the level of omega-3 polyunsaturated fatty acids eicosapentenoic [DHA, 22 6 n-3], are significantly [P < 0.01] decreased and this makes membrane more rigid and less permeable